Treats a type of cancer called cutaneous T-cell lymphoma (CTCL).
IstodaxThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not receive this medicine if you have had an allergic reaction to romidepsin, or if you are pregnant.
How to Use This Medicine:
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
- A nurse or other trained health professional will give you this medicine.
- This medicine is usually given on Day 1, Day 8, and Day 15 of a 28-day cycle treatment. This 3-day treatment is given again every 28 days until your body responds to the medicine. Each treatment usually takes about 4 hours.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using St. John's wort, medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, procainamide, propafenone, quinidine, sotalol, Betapace®, Cardioquin®, Cordarone®, Norpace®, Quinaglute®, Procanbid®, Rythmol®, Tambocor®, or Tikosyn®), medicine to treat HIV or AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Norvir®, or Viracept®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Biaxin®, Ketek®, Nizoral®, or Sporanox®), or medicine to treat depression (such as nefazodone, Serzone®). Tell your doctor if you are also using dexamethasone (Decadron®), medicine for seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, or Tegretol®), medicine for tuberculosis (rifabutin, rifampin, rifapentine, Mycobutin®, Priftin®, Rifadin®, or Rimactane®), or a blood thinner (such as warfarin, Coumadin®).
- Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use another form of birth control along with your birth control pills. Other forms include condoms, a diaphragm, or a contraceptive foam or jelly.
Warnings While Using This Medicine:
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems (such as congenital long QT syndrome), or high or low potassium or magnesium in the blood.
- This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
- This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats; chest pain; or shortness of breath.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
- Chest pain or shortness of breath.
- Confusion, weakness, and muscle twitching.
- Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
- Fast, pounding, or uneven heartbeat.
- Fever, chills, cough, sore throat, and body aches.
- Increased hunger or thirst.
- Lightheadedness, dizziness, or fainting.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding or bruising.
If you notice these less serious side effects, talk with your doctor:
- Change or loss of taste.
- Diarrhea, constipation, or loss of appetite.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 1/4/2011
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