Brimonidine/timolol (Into the eye)
Brimonidine Tartrate, Timolol Maleate (TIM-oh-lol MAL-ee-ate)
Treats increased pressure in the eye that is caused by glaucoma or a condition called ocular (eye) hypertension.
CombiganThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not use this medicine if you have had an allergic reaction to brimonidine or timolol, or if you have asthma, slow heartbeat, severe chronic obstructive pulmonary disease (COPD), heart block, or heart failure.
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Wash your hands with soap and water before and after using this medicine.
- Shake the eye drops well just before each use.
- Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.
- To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.
- You should not use this medicine if you have contact lenses in your eyes. Remove your contact lenses before you use this medicine.
- If your doctor ordered two different eye medicines to be used together, wait at least 5 minutes before using the second medicine. This will help prevent the second medicine from "washing out" the first one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using digoxin (Lanoxin®, Digitek®), quinidine (Cardioquin®, Quinaglute®), or reserpine. Tell your doctor if you are using medicine to lower blood pressure (such as atenolol, hydrochlorothiazide [HCTZ], lisinopril, metoprolol, quinapril, Accupril®, Cozaar®, Diovan®, Lotrel®, Norvasc®, Toprol®, Zestril®), medicine to treat depression (such as amitriptyline, doxepin, nortriptyline, Elavil®, Pamelor®, Sinequan®) or an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, Parnate®).
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have lung disease, heart disease, blood vessel disorder (such as Raynaud's phenomenon or thromboangiitis obliterans), a history of stroke, depression, lightheadedness or fainting caused by low blood pressure, diabetes, overactive thyroid, or severe muscle weakness.
- This medicine may raise or lower your blood sugar, or it may cover up symptoms of very low blood sugar (hypoglycemia).
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
- If you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
- This medicine may cause blurred vision or other vision problems that may last for several minutes after you put them in your eye. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
- Blurred or other changes in vision.
- Burning, dry, itching, or stinging in the eyes.
- Chest pain or discomfort.
- Rapid weight gain.
- Redness, pain, swelling of eye, eyelid, or inner lining of eyelid.
- Sensitivity of eyes to light.
- Shortness of breath.
- Slow, fast, or irregular heartbeat.
- Swelling in your hands, ankles, or feet.
- Unusual tiredness or weakness.
If you notice these less serious side effects, talk with your doctor:
- Dizziness or drowsiness.
- Dry mouth.
- Loss of appetite.
- Mood or mental changes.
- Trouble sleeping.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 1/4/2011
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